Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1[S]
Posttranslational modification by isolevuglandins (isoLGs), arachidonate oxidation products, is here an important yet understudied process associated with altered protein properties.This type of modification is detected in cytochrome P450 27A1 (CYP27A1), a multifunction enzyme expressed in almost every cell and involved in the metabolism of cholest